How long does it take for diflucan to work. Clotrimazole / miconazole) or long other take ingredients in take the take product taking allergy work drugs (e.g. Stop taking Diflucan how and consult your diflucan doctor long if you experience palpitations and dizziness or blackouts. How long does fluconazole actually take to start reducing the symptoms for a yeast infection? I have never had a yeast infection before, unfortunately i was prescribed some antibiotics for a urinary tract infection, and the side effect was lo and behold.a yeast infection! TheBody.com fills you in on the topic, how long does diflucan take to work, with a wealth of fact sheets, expert advice, community perspective, the latest news/research, and much more. Skip to. How Long Does Diflucan Take to Work For mild, uncomplicated, infections Diflucan is prescribed as a single 150 mg dose and an improvement in symptoms is usually seen within one to three days. If a single dose does not completely relieve symptoms, or the infection is severe, Diflucan can be prescribed as three consecutive doses given three days apart. Fluconazole, or Diflucan, begins to work in one to three days, and symptoms may take up to seven days to completely disappear, according to C-Health from MediResource. How Long Does It Take For Diflucan To Work When trying to see how long it takes for Diflucan to work, take the typical dose into consideration. Diflucan, when prescribed in 150mg oral capsules, should start to work within one day of taking the medication but it can take as long as three to seven days for the infection to clear up and for symptoms to improve. Clear, concise explanations from Doctors: Dr. Lin discusses the uses and doses of fluconazole, and how long it takes to clear your system completely. Clear, concise explanations from Doctors: Dr. Lin discusses the uses and doses of fluconazole, and how long it takes to clear your system completely. How long does Diflucan take to work? I took it last night, but now my symptoms feel like they are worse. I had a bunch of white discharge come out today, but my vaginal area is very sore and there are still some fire engine red spots of skin down there. You should begin to notice a decrease in the yeast infection symptoms within 1-3 days. If not you might not have yeast infection or need a second dose for more severe yeast infection.